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US FDA advises COVID vaccine makers to develop shots aimed at XBB.1.5 variant

© Reuters. FILE PHOTO: A woman holds a small bottle labelled with a “Coronavirus COVID-19 Vaccine” sticker and a medical syringe in this illustration taken October 30, 2020. REUTERS/Dado Ruvic/File Photo

(Reuters) – The U.S. Food and Drug Administration (FDA) said on Friday it has advised manufacturers that are updating their COVID-19 vaccines to develop monovalent shots to target the XBB.1.5 subvariant.

So-called monovalent, or single-target vaccines, would be a change from the most recent bivalent COVID boosters that targeted both the original and Omicron strains of the coronavirus.

The FDA’s advice comes a day after its panel of experts unanimously recommended that the updated COVID shots being developed for a fall vaccination campaign target one of the currently dominant XBB coronavirus variants.

COVID vaccine makers Pfizer/BioNTech, Moderna (NASDAQ:) and Novavax (NASDAQ:) are already developing versions of their respective vaccines to target XBB.1.5 and other currently circulating subvariants.

Novavax’s XBB.1.5 COVID vaccine candidate is being manufactured at commercial scale, with plans for it to be in the market for the fall campaign, the company said on Friday.

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