{"id":27733,"date":"2023-06-26T15:42:44","date_gmt":"2023-06-26T19:42:44","guid":{"rendered":"https:\/\/ifintechworld.com\/uncategorized\/experimental-lilly-pill-mounjaro-both-lead-to-15-weight-loss-in-clinical-trials\/"},"modified":"2023-06-26T15:42:45","modified_gmt":"2023-06-26T19:42:45","slug":"experimental-lilly-pill-mounjaro-both-lead-to-15-weight-loss-in-clinical-trials","status":"publish","type":"post","link":"https:\/\/ifintechworld.com\/?p=27733","title":{"rendered":"Experimental Lilly pill, Mounjaro both lead to 15% weight loss in clinical trials"},"content":{"rendered":"
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\u00a9 Reuters. FILE PHOTO: Eli Lilly logo is shown on one of the company’s offices in San Diego, California, U.S., September 17, 2020. REUTERS\/Mike Blake\/File Photo<\/span>
\n<\/i>\n<\/div>\n

By Deena Beasley<\/p>\n

(Reuters) -In a mid-stage trial, the highest dose of Eli Lilly (NYSE:)’s experimental pill orforglipron led to 14.7% weight loss after 36 weeks for people who were obese or overweight, setting a marker in the race to develop effective oral obesity drugs, researchers said on Friday.<\/p>\n

Results from a different trial, also presented in San Diego at the annual meeting of the American Diabetes Association, showed that Lilly’s injected drug Mounjaro helped people with type 2 diabetes who were also obese or overweight lose an average of 15% of their body weight, or 33 pounds (14.8 kg). <\/p>\n

Both drugs belong to a new class known as incretins that have reignited researcher and investor interest in the weight-loss treatment market, which is estimated to reach $100 billion by the end of the decade. <\/p>\n

At the multi-dose trial’s 26-week main endpoint, Lilly said once-daily orforglipron showed statistically significant dose-dependent body weight reductions ranging from 8.6% (12mg) to 12.6% (45mg), compared with 2% for the placebo group.<\/p>\n

For patients on orforglipron, the company said body weight continued to decrease at 36 weeks, with reductions ranging from 9.4% to 14.7%.<\/p>\n

Lilly said the safety profile of orforglipron was similar to other incretin-based therapies, with gastrointestinal side effects the most common, generally mild-to-moderate and usually occurring during the initial dose escalation period.<\/p>\n

Orforglipron, like Mounjaro and Novo Nordisk (NYSE:)’s Ozempic and Wegovy, are designed to activate hormones that regulate blood sugar, slow stomach emptying and decrease appetite.<\/p>\n

Novo Nordisk is scheduled to present trial results for its oral obesity drug candidate at the diabetes meeting on Sunday. Pfizer <\/span><\/span> (NYSE:) is also developing pills to treat obesity.<\/p>\n

In the phase 3, 938-person study of obese diabetics, Mounjaro, also known as tirzepatide, was given as a once weekly injection. <\/p>\n

Lilly had announced in April the 72-week trial’s “top line” results and said it expects the U.S. Food and Drug Administration to decide as early as late 2023 whether to approve Mounjaro as an obesity treatment.<\/p>\n

Lilly reported last year that a trial of Mounjaro in people who were obese or overweight but did not have diabetes found it led to weight loss of 22.5%, or about 52 pounds (24kg). <\/p>\n

\u201cWe recognize that obesity is a global epidemic and there is a need for a variety of effective medications and administration routes,\u201d weight-loss specialist Dr. Sean Wharton said in a statement. <\/p>\n

Lilly is slated to announce later on Friday results from a different Phase 2 trial of orforglipron designed to evaluate the drug as a treatment for adults with type 2 diabetes.<\/p>\n

The company is conducting Phase 3 trials of orforglipron for chronic weight management and for type 2 diabetes.<\/p>\n

Results from the Phase 2 study of orforglipron were also published in the New England Journal of Medicine, while the Mounjaro data was published in the Lancet. <\/p>\n<\/div>\n

Read the full article here<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a9 Reuters. FILE PHOTO: Eli Lilly logo is shown on one of the company’s offices in San Diego, California, U.S., September 17, 2020. REUTERS\/Mike Blake\/File Photo By Deena Beasley (Reuters) -In a mid-stage trial, the highest dose of Eli Lilly (NYSE:)’s experimental pill orforglipron led to 14.7% weight loss after 36 weeks for people who […]<\/p>\n","protected":false},"author":1,"featured_media":27734,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"video","meta":{"footnotes":""},"categories":[1],"tags":[83],"class_list":["post-27733","post","type-post","status-publish","format-video","has-post-thumbnail","hentry","category-uncategorized","tag-featured","post_format-post-format-video"],"yoast_head":"\nExperimental Lilly pill, Mounjaro both lead to 15% weight loss in clinical trials | iFintechWorld<\/title>\n<meta name=\"description\" content=\"\u00a9 Reuters. 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